Biotransformation of Perrottetin F by Aspergillus niger: New Bioactive Secondary Metabolites

Biotransformation of bis-bibenzyl perrottetin F (1), isolated from the liverwort Lunularia cruciata by Aspergillus niger, has been investigated. New metabolites (2-4) have using reversed phase semipreparative HPLC and their structures were established to be 8-hydroxyperrottetin F, C-7-C-8 cleaved product, 6’-sulfate 1D 2D NMR, HR-ESI-MS, IR UV spectroscopy. The antimicrobial cytotoxic properties these compounds also evaluated. Given suggested parent compound, antiproliferative activity against healthy human lung fibroblasts (MRC5) carcinoma (A549) three evaluated revealing lower in comparison starting compound - F. evaluated, with inhibitory Pseudomonas aeruginosa PAO1 Staphylococcus aureus determined between 100 µM 450 µM. showed remarkable ability inhibit synthesis bacterial quorum-sensing signal molecules such as short chain acyl homoserine lactones (AHLs). Therefore, biotransformation method represents fast effective tool for obtaining new bioactive structures.